1600 - 5,000 to 7,000 Susquehannock indians live in the area.
1608 - Captain John Smith travels up the Susquehanna.
1642 - Maryland governor orders Susquehannock indians shot on sight.
1649 - Susquehannocks fight Virgina Puritans in northern Maryland.
1652 - Susquehannocks sign treaty, give up all Maryland claims.
1654 - Smallpox hits the Susquehannock indian villages.
1656 - Susquehannocks end 6 year long war, make peace with the Mohawks.
1661 - Smallpox decimates the Susquehannock, population never recovers.
1669 - Susquehannocks down to only 300 warriors.
1675 - Susquehannock indians decimated by war with the Iroquois.
1676 - Susquehannock surrender to the Iroquois, move to Mohawk lands.
1706 - Iroquois allow 300 Susquehannocks to move back to central PA.
1719 - John Harris Sr. settled at present day Harrisburg.
1727 - John Harris, founder of Harrisburg born.
1730 - Hanover settled.
1730 - Shippensburg settled in July 1730 along Burds Run.
1735 - Widow Pipers Tavern built in Shippensburg.
1733 - John Harris Sr. aqquires 800 acre land grant at Harrisburg
1737 - Monaghan Presbyterian Church founded in present day Dillsburg.
1737 - Boiling Springs area settled.
1737 - Big Spring Presbyterian Meeting House erected.
1740 - Greater Conewago Presbyterian Church formed in Hunterstown.
1740 - Old Paxton Presbyterian Church built in Paxtang.
1740 - Fort Franklin (log fort) built near Shippensburg.
1741 - York founded by settlers from the Philadelphia area.
1741 - Hunterstown founded.
1745 - Monaghan Township formed.
1745 - Warrington Friends Meeting House established near Wellsville.
1749 - York County created from Lancaster County August 19, 1749.
1751 - Carlisle laid out by Scots-Irish immigrants.
1753 - Benjamin Franklin stayed at the Green Tree Inn, Carlisle.
1763 - The last 20 Susquehannock indians were killed by Paxton Boys mob.
1764 - James Joner laid out Dover on 203 acres, called Jonerstown until 1815.
1773 - Dickinson College founded at Carlisle.
1775 - Cumberland Riflemen fight in Quebec.
1782 - Carlisle incorporated as borough on April 13, 1782.
1783 - Dickinson College chartered.
1785 - Harrisburg laid out and surveyed.
1785 - Dauphin County was created from Lancaster County.
1787 - York incorporated as a borough on Sept. 24, 1787.
1787 - Riot at Carlisle against a planned march in favor of US constitution.
1790 - Newville laid out by Big Spring Presbyterian Church trustees.
1791 - Harrisburg incorporated.
1791 - The "Oracle of Dauphin", first local newspaper published.
1793 - George Washington has his horse shod at Hunterstown.
1793 - Federal troops assemble at Carlisle during the Whiskey Rebellion.
1795 - Failed attempt to move state capital to Carlisle.
1797 - Conewago Canal built near York Haven.
1797 - Earliest note of Encampment of Knights Templar at Harrisburg.
1798 - First public execution at Harrisburg
1799 - George and Martha Washington visit York Sulphur Springs resort.
1806 - Mechanicsburg area settled.
1809 - Harrisburg Academy established.
1812 - Harrisburg named state capitol.
1814 - Harrisburg Bible Society established.
1814 - Harrisburg Bank chartered with $300,000 capital.
1815 - Hanover incorporated as a borough.
1816 - The Harrisburg Bridge opens, toll houses completed 1817.
1819 - Shippensburg incorporated as a borough on January 21.
1820 - David "Robber" Lewis, the Robin Hood of PA, died.
1824 - State approved the construction of the Pennsylvania Canal.
1825 - Gen. Lafayette and son visit Middletown and Harrisburg.
1825 - Riot at Harrisburg over a captured runaway slave.
1825 - First steamboats arrive on the Susquehanna at Harrisburg.
1826 - Lutheran Theological Seminary founded at Gettysburg.
1828 - Mechanicsburg incorporated as a borough on April 12, 1828.
1828 - Harrisburg Masonic Lodge closes due to public distrust.
1828 - First water in Pennsylvania Canal at Harrisburg.
1831 - New Cumberland incorporated as a borough on March 21, 1831.
1831 - Great Snow Storm, over 2' of drifting snow buries the area.
1832 - Gettysburg College founded.
1833 - The Great Meteor Shower was witnessed by area residents.
1834 - Dickinson School of Law founded at Dickinson College in Carlisle.
1835 - Joseph Ritner, Governor 1835-1839
1836 - The first locomotive train arrives in Harrisburg from Middletown.
1837 - Cumberland Valley Rail Road opens from Lemoyne to Chambersburg.
1839 - Railroad bridge across the Susquehanna to Harrisburg completed.
1839 - Harrisburg Sunday School Teachers Union formed.
1841 - Harrisburg builds new $40,000 prison.
1841 - Harrisburg Water Works completed.
1841 - Harrisburg Masonic Lodge reopens after 13 year closure.
1845 - Harrisburg Cemetary Association incorporated on Feb 14.
1846 - Flood takes out two Susquehanna bridges at Harrisburg.
1847 - Iron ore discovered in Dillsburg.
1849 - Harrisburg Female Seminary established.
1850 - Harrisburg Gas Company incorporated.
1850 - "American Whig", first daily Harrisburg newspaper.
1851 - Harrisburg Lunatic Hospital completed on 130 acre farm.
1852 - Harrisburg Borough Item newspaper founded by George Crap.
1853 - Pennsylvania Female College established at Harrisburg.
1857 - State sold the Pennsylvania Canal to Pennsylvania Railroad.
1857 - Harrisburg Building Association established.
1857 - Irving Female College established in Mechanicsburg.
1864 - Dover incorporated.
1866 - Pennsylvania Steel Company opens in Steelton.
1871 - The Normal School founded, now known as Shippensburg University.
1872 - Dillsburg branch of the railroad completed.
1872 - First Granger's Picnic at Williams Grove.
1885 - Camp Hill incorporated as a borough on November 10, 1885.
1887 - York incorporated as a city.
1905 - Lemoyne (formerly Bridgeport)incorporated as borough on May 23, 1905.
1906 - Thomas Edison visited local mining operations.
1917 - The first Pennsylvania Farm Show held at Harrisburg.
1929 - Irving Female College in Mechanicsburg closes.
1936 - Last train through downtown Carlisle on Oct. 17, 1936.
1949 - Allenberry Playhouse opens at Boiling Springs.
1972 - Hurricane Agnes brings major flood in June 1972.
1979 - Three Mile Island nuclear disaster March 28, 1979.
